Molecular mechanisms of β2-microglobulin amyloid fibril formation
نویسندگان
چکیده
منابع مشابه
The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH
RATIONALE Amyloid formation is implicated in a number of human diseases. β(2)-Microglobulin (β(2)m) is the precursor protein in dialysis-related amyloidosis and it has been shown that partial, or more complete, unfolding is key to amyloid fibril formation in this pathology. Here the relationship between conformational flexibility and β(2)m amyloid formation at physiological pH has been investig...
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ژورنال
عنوان ژورنال: SEIBUTSU BUTSURI KAGAKU
سال: 2010
ISSN: 0031-9082,1349-9785
DOI: 10.2198/sbk.54.13